abstract:CONTEXT:Icariin (ICA) is the main active ingredient of Epimedium brevicornu Maxim (Berberidaceae), which is used in the immune, reproductive, neuroendocrine systems, and anti-aging. OBJECTIVE:To evaluate the effect of ICA on natural aging rat. MATERIALS AND METHODS:16-month-old Sprague-Dawley (SD) rats were randomly ...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1878238
更新日期:2021-12-01 00:00:00
abstract::In this study, Xuzhou, a typical industrial city in the north of Jiangsu Province, was chosen to investigate the pollution level of atmospheric particulates. The proportion of fine particles (PM2.5) in PM10 is larger than that of coarse particles (about 58%). The physicochemical properties of PM2.5 were analyzed by SE...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1885223
更新日期:2021-12-01 00:00:00
abstract::The emergence of New Delhi Metallo-β-lactamase (NDM)-producing Klebsiella pneumoniae has aroused critical concern worldwide. Herein, we reported the first emergence of NDM-5-producing K. pneumoniae isolates in a 68-year-old lung transplant recipient, who died of septic shock 13 days after surgery. The K. pneumoniae st...
journal_title:Emerging microbes & infectionspub_type: 信件
doi:10.1080/22221751.2021.1889932
更新日期:2021-12-01 00:00:00
abstract::Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors are the most relevant anti-tubulin polymerisation agents. Thus, new quinoline derivatives have been designed and synthesised to possess the same essential pharma...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1883598
更新日期:2021-12-01 00:00:00
abstract::Native nanostructured lipoproteins such as low- and high-density lipoproteins (LDL and HDL) are powerful tools for the targeted delivery of drugs and imaging agents. While the cellular recognition of well-known HDL-based carriers occurs via interactions with an HDL receptor, the selective delivery and uptake of LDL pa...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1886199
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Intermediate-risk acute myeloid leukemia (IR-AML) without FLT3-ITD, NPM1 and biallelic CEBPA mutations (here referred to as NPM1mut-negCEBPAdm-negFLT3-ITDneg AML) is a clinically heterogeneous disease. The optimal post-remission therapy (PRT) is unclear for patients with NPM1mut-negCEBPAdm-negFLT3-ITDneg AML...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1880753
更新日期:2021-12-01 00:00:00
abstract::Previous studies have identified numerous risk factors of contrast-induced acute kidney injury (CI-AKI) in patients undergoing coronary angiography. However, the association between anemia and CI-AKI remains conflicting. Thus, we conducted a meta-analysis to further clarify the relationship between anemia and CI-AKI. ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1883887
更新日期:2021-12-01 00:00:00
abstract::Sexual and reproductive health needs and access are often neglected during health emergencies. The 2015/2016 Zika epidemic is an example of priorities shifting to the detriment of women's health needs. The internet is a key tool for abortion knowledge sharing and seeking in countries where abortion is not legally avai...
journal_title:Sexual and reproductive health matterspub_type: 杂志文章
doi:10.1080/26410397.2021.1883804
更新日期:2021-12-01 00:00:00
abstract::Introduction: Telesimulation may allow simulationists to continue with essential simulation-based training programs during the COVID-19 pandemic. Hence, we investigated the feasibility of telesimulation for neonatal resuscitation training, assessed participants' attitudes towards telesimulation as well as its effect o...
journal_title:Medical education onlinepub_type: 杂志文章
doi:10.1080/10872981.2021.1892017
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:Finland was the first European country to introduce a nation-wide mandatory seasonal influenza vaccination policy for healthcare workers (HCWs) by mandating that administrators of health care institutions only employ vaccinated HCWs. In this study, we examine the effects of the new policy and the view of H...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1889022
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Primary gastrointestinal lymphoma (PGIL), an uncommon subtype of lymphoma, accounts for 1%-4% of gastrointestinal cancers. This study, therefore, aimed to investigate the current 10-year epidemiology and outcomes of PGIL. METHODS:This retrospective study involved a hospital-based chart review to analyze the...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1889160
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Guizhi-Shaoyao-Zhimu decoction (GSZD) is commonly used to treat rheumatoid arthritis (RA), but its mechanism is unclear. OBJECTIVE:To investigate the effect of GSZD on bone erosion in type II collagen (CII)-induced arthritis (CIA) in rats and to identify the underlying mechanism. MATERIALS AND METHODS:The CIA...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1876100
更新日期:2021-12-01 00:00:00
abstract::Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed an RNA-expression a...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1889815
更新日期:2021-12-01 00:00:00
abstract:INTRODUCTION:It has been demonstrated that urinary neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin are helpful biomarkers in the differentiation of intrinsic and prerenal acute kidney injury. OBJECTIVE:The present cross-sectional study investigates, whether urinary biomarkers are able to differentia...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1885442
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Re-yan-ning mixture (RYNM) is a new national drug approved by China's State Food and Drug Administration for the treatment of colds, simple pneumonia and acute bronchitis. OBJECTIVE:To determine the mechanism of action of RYNM in the treatment of bacterial pneumonia. MATERIALS AND METHODS:Using the network ph...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2021.1872653
更新日期:2021-12-01 00:00:00
abstract::Cervical cancer is one of the most common causes of cancer deaths in women due to poor prognosis and high mortality rates. A novel mRNA-miRNA-lncRNA signature linked to prognosis of cervical cancer is needed to help clinicians judge the prognosis of individual patients more accurately. On the basis of GEO datasets, a ...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1890377
更新日期:2021-12-01 00:00:00
abstract::Biofilm-associated polymicrobial infections tend to be challenging to treat. Candida albicans and Staphylococcus aureus are leading pathogens due to their ability to form biofilms on medical devices. However, the therapeutic implications of their interactions in a host is largely unexplored. In this study, we used a m...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1894834
更新日期:2021-12-01 00:00:00
abstract::Evolved metabolic thriftiness in humans is a proposed contributor to the obesity epidemic. Insect models have been shown to evolve both 'metabolic thrift' in response to rearing on high-protein diets that promote leanness, and 'obesity resistance' when reared on fattening high-carbohydrate, low-protein foods. Despite ...
journal_title:Flypub_type: 杂志文章
doi:10.1080/19336934.2021.1896960
更新日期:2021-12-01 00:00:00
abstract::We report the formulation of nanoassemblies (NAs) comprising C225 conjugates Gd-PFH-NAs (C-Gd-PFH-NAs) for low-intensity focused ultrasound diagnosis ablation of thyroid cancer. C-Gd-PFH-NAs showed excellent stability in water, phosphate-buffered saline (PBS), and 20% rat serum. Transmission electron microscopy (TEM) ...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1889721
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:The uric acid metabolism pathway is more similar in primates and humans than in rodents. However, there are no reports of using primates to establish animal models of hyperuricaemia (HUA). OBJECTIVES:To establish an animal model highly related to HUA in humans. MATERIALS AND METHODS:Inosine (75, 100 and 200 m...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1871373
更新日期:2021-12-01 00:00:00
abstract::A novel approach for the utilisation of fruit waste is attempted in the present investigation. Mangifera indica seed aqueous extract was utilised for green synthesis of silver nanoparticles (AgNPs). The phytoconstituents in the seed acted as reducing and stabilising agent for AgNP formation. UV-Vis, Zeta potential, FT...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1899193
更新日期:2021-12-01 00:00:00
abstract::Seasonal human coronaviruses (HCoVs) including HCoV-229E, -OC43, -NL63, and -HKU1 widely spread in global human populations. However, the relevance of humoral response against seasonal HCoVs to COVID-19 pathogenesis is elusive. In this study, we profiled the temporal changes of IgG antibody against spike proteins (S-I...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1905488
更新日期:2021-12-01 00:00:00
abstract::Cartilage damage continues to pose a threat to humans, but no treatment is currently available to fully restore cartilage function. In this study, a new class of composite hydrogels derived from water-soluble chitosan (CS)/hyaluronic acid (HA) and silanized-hydroxypropyl methylcellulose (Si-HPMC) (CS/HA/Si-HPMC) has b...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1895906
更新日期:2021-12-01 00:00:00
abstract::Yiqi Huoxue Recipe (YHR) is commonly used in China to treat diseases such as heart failure (HF). It has been reported that YHR can treat HF and has a certain protective effect on myocardial cell damage. The purpose of this study is to determine the cardioprotective effects of YHR on HF-induced apoptosis and to clarify...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1900634
更新日期:2021-12-01 00:00:00
abstract::Hand, Foot and Mouth Disease (HFMD) is usually a self-limiting, mild childhood disease that is caused mainly by Coxsackie virus A16 (CVA16) and Enterovirus A71 (EV-A71), both members of the Picornaviridae family. However, recurring HFMD outbreaks and epidemics due to EV-A71 infection in the Western Pacific region, and...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1906754
更新日期:2021-12-01 00:00:00
abstract::Usutu virus (USUV; family: Flaviviridae, genus: Flavivirus), is an emerging zoonotic arbovirus that causes severe neuroinvasive disease in humans and has been implicated in the loss of breeding bird populations in Europe. USUV is maintained in an enzootic cycle between ornithophilic mosquitos and wild birds. As a memb...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1908850
更新日期:2021-12-01 00:00:00
abstract::Background: Recent evidence indicates that host-gut microbiota crosstalk has nonnegligible effects on host skeletal muscle, yet gut microbiota-regulating mechanisms remain obscure.Methods: C57BL/6 mice were treated with a cocktail of antibiotics (Abx) to depress gut microbiota for 4 weeks. The profiles of gut microbio...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2021.1900593
更新日期:2021-12-01 00:00:00
abstract::Purpose: This study aims to explore negotiations of hope in everyday life for families where a child with spinal muscular atrophy (SMA) has received a new drug treatment.Methods: A narrative design was used, drawing on interviews and participant observations in two families with children with SMA, types 1-2, to situat...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1904722
更新日期:2021-12-01 00:00:00
abstract::Porcine deltacoronavirus (PDCoV) is a potentially emerging zoonotic pathogen that causes severe diarrhea in young pigs, with a risk of fatal dehydration. Its pathogenicity on neonatal piglet has been previously reported, however, it is less known if the coinfection with immunosuppressive pathogens can influence PDCoV ...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1908742
更新日期:2021-12-01 00:00:00
abstract::Phenotypic switching is the main cause of the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). We previously showed that Daxx exerted negative regulatory effect on AngII-induced VSMC proliferation and migration. However, the function of Daxx in VSMC phenotype switching remained unknown. Ni...
journal_title:Cell adhesion & migrationpub_type: 杂志文章
doi:10.1080/19336918.2021.1909899
更新日期:2021-12-01 00:00:00
abstract::Clostridium perfringens is an extremely versatile pathogen of humans and livestock, causing wound infections like gas gangrene (clostridial myonecrosis), enteritis/enterocolitis (including one of the most common human food-borne illnesses), and enterotoxemia (where toxins produced in the intestine are absorbed and dam...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2021.1886777
更新日期:2021-12-01 00:00:00
abstract::This paper explores how HIV-positive abakhwetha (young male initiates) undergoing ulwaluko (traditional Xhosa initiation and circumcision) engage with HIV-related biomedical care and treatment. Health-focused life history narratives (n = 36), semi-structured interviews (n = 32) and analysis of health facility files (n...
journal_title:SAHARA J : journal of Social Aspects of HIV/AIDS Research Alliancepub_type: 杂志文章
doi:10.1080/17290376.2021.1894225
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVES:The primary objective was to compare the efficacy of intermediate-dose cytarabine (IDAC) and high-dose cytarabine (HiDAC) as consolidation chemotherapy for acute myeloid leukemia (AML) in terms of a one-year-relapse-free survival rate (RFS). The secondary objectives were one-year-overall survival rate (OS) a...
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2021.1912949
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Naoxintong capsule (NXT) is one of the most prevalent Traditional Chinese Medicine formulations in the treatment of coronary heart disease (CHD), yet the action of pharmacodynamic components remains unclear. OBJECTIVE:To determine the basis by which pharmacodynamic components of NXT may be effective in the tre...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1870506
更新日期:2021-12-01 00:00:00
abstract::Mutations in the SARS-CoV-2 Membrane (M) gene are relatively uncommon. The M gene encodes the most abundant viral structural protein, and is implicated in multiple viral functions, including initial attachment to the host cell via heparin sulphate proteoglycan, viral protein assembly in conjunction with the N and E ge...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2021.1922097
更新日期:2021-12-01 00:00:00
abstract::The aim of this work was to compare the prevalence of opisthorchiasis, diphyllobothriasis, and ascariasis among the rural indigenous and long-term resident people of Khanty-Mansi Autonomous Okrug (KMAO) in the years 1988-89 and 2018-19. Helminth infections were identified by faecal microscopic examinations conducted d...
journal_title:International journal of circumpolar healthpub_type: 杂志文章
doi:10.1080/22423982.2021.1917270
更新日期:2021-12-01 00:00:00
abstract::Sepsis-induced acute respiratory distress syndrome (ARDS) remains a major threat to human health without effective therapeutic drugs. Previous studies demonstrated the power of gene expression profiling to reveal pathological changes associated with sepsis-induced ARDS. However, there is still a lack of systematic dat...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1917981
更新日期:2021-12-01 00:00:00
abstract::In vitro cultures of primary cortical neurons are widely used to investigate neuronal function. However, it has yet to be fully investigated whether there are significant differences in development and function between cultured rodent and primate cortical neurons, and whether these differences influence the utilizatio...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313056
更新日期:2021-12-01 00:00:00
abstract::The expression of major histocompatibility complex class I (MHC-I), a key antigen-presenting protein, can be induced in dopaminergic neurons in the substantia nigra, thus indicating its possible involvement in the occurrence and development of Parkinson's disease. However, it remains unclear whether oxidative stress i...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313057
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to explore the effectiveness of thiamin and folic acid supplementation on the improvement of the cognitive function in patients with maintenance hemodialysis. METHOD:In the present study, we randomly assigned patients undergoing hemodialysis who had the Montreal Cognitive Assessment (MoCA) s...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1914656
更新日期:2021-12-01 00:00:00